The potential use of Reactive Oxygen gel in surgical prophylaxis

  • Matthew Dryden
    Affiliations
    Matthew Dryden MD FRCPath FRCPS Department of Infection and Microbiology, Hampshire Hospitals Foundation NHS Trust and Southampton University Medical School, Southampton, UK. Conflicts of interest: none declared
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Published:October 25, 2021DOI:https://doi.org/10.1016/j.mpsur.2021.09.011

      Abstract

      The principles of antibiotic use in surgical prophylaxis remain the same. The purpose of this review is to introduce the investigational agent Reactive Oxygen as a possible surgical prophylaxis agent, particularly in the light of the global crisis in antibiotic resistance. There is evidence for its efficacy in the treatment of infected soft tissue and early clinical data for its efficacy in reducing infection in clean surgery (caesarean section), and in complex contaminated surgery (abdominal wall repair and prosthetic joint salvage).

      Keywords

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      References

        • Dryden M.
        Surgical antibiotic prophylaxis.
        Surgery. 2019; 37: 19-25
      1. https://amr-review.org/.

        • Dryden M.
        Reactive oxygen species treatment in the management of wounds.
        Wounds U K. 2017; 13: 26-33
        • Dryden M.
        Reactive oxygen therapy: a novel antimicrobial.
        Int J Antimicrob Agents. 2018 Mar; 51 (Epub 2017 Sep 5): 299-303https://doi.org/10.1016/j.ijantimicag.2017.08.029
        • Cooke J.
        • Dryden M.
        • Patton T.
        • Brennan J.
        • Barrett J.
        The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide.
        BMC Res Notes. 2015; 8 (Accepted by): 20https://doi.org/10.1186/s13104-014-0960-4
        • Dunnill C.
        • Patton T.
        • Brennan J.
        • et al.
        Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process.
        Int Wound J. 2017; 14: 89-96
        • Dryden M.
        • Lockyer G.
        • Saeed K.
        • Cooke J.
        Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment.
        J Glob Antib Res. 2014; https://doi.org/10.1016/j.jgar.2014.03.006
        • Dryden M.S.
        • Cooke J.
        • Salib R.
        • et al.
        Hot Topics in Reactive Oxygen therapy: antimicrobial and immunological mechanisms, safety, and clinical applications.
        J Glob Antib Res. 2017; (pii: S2213-7165(17)30024-3)https://doi.org/10.1016/j.jgar.2016.12.012
        • Dryden M.
        • Dickinson A.
        • Brooks J.
        • Hudgell L.
        • Saeed K.
        • Cutting K.
        A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds.
        J Wound Care. 2016; 25 ([Observational study providing clinical evidence for RO in soft tissue infection]): 140-146
        • Dryden M.
        • Milward G.
        • Saeed K.
        Infection prevention in wounds with Surgihoney.
        J Hosp Infect. 2014 Oct; 88 (Epub 2014 Aug 1): 121-122https://doi.org/10.1016/j.jhin.2014.07.008
        • Dryden M.
        • Goddard C.
        • Madadi A.
        • Heard M.
        • Saeed K.
        • Cooke J.
        Bioengineered Surgihoney as an antimicrobial wound dressing to prevent Caesarean wound infection: a clinical and cost-effectiveness study.
        Br J Midwifery. 2014; 22 ([Temporal open trial providing early evidence for efficacy or RO in surgical prophylaxis]): 23-27
        • Dryden M.
        • Tawse C.
        • Adams J.
        • Saeed K.
        • Cooke J.
        The use of Surgihoney to prevent or eradicate bacterial colonisation in dressing oncology long vascular lines.
        J Wound Care. 2014; 23: 338-341
        • Davis S.
        • Martinez L.
        • Kirsner R.
        The diabetic foot: the importance of biofilms and wound bed preparation.
        Curr Diabetes Rep. 2006; 6: 439-445
        • Halstead F.D.
        • Webber M.A.
        • Rauf M.
        • Burt R.
        • Dryden M.S.
        • Oppenheim B.A.
        In vitro activity of an engineered honey, medical-grade honeys, and antimicrobial wound dressings against biofilm-producing clinical bacterial isolates.
        J Wound Care. 2016; 25: 93-102
        • Wloch C.
        • Wilson J.
        • Lamagni T.
        • Harrington P.
        • Charlett A.
        • Sheridan E.
        Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study.
        BJOG An Int J Obstet Gynaecol. 2012; 119: 1324-1333
        • Khan W.
        • Williams R.
        • Metah A.
        • Morgan-Jones R.
        Surgihoney as a novel antimicrobial coating in salvage revision total knee arthroplasty.
        Orthopaedic Pro. 2015; 97 ([ISSN]): 66
        • Parker S.
        • Pavolovic T.
        • Patel R.
        • et al.
        Impact of Surgihoney Reactive Oxygen on surgical site infection (SSI) after complex abdominal wall reconstruction (AWR) of grade 3 and 4 ventral Hernias: a single arm pilot study.
        Int J Surg Protoc. 2017 22; 5 (eCollection 2017): 18-21https://doi.org/10.1016/j.isjp.2017.07.001
        • Davis K.A.
        • Moran K.A.
        • McAllister C.K.
        • Gray P.J.
        Multidrug-resistant Acinetobacter extremity infections in soldiers.
        Emerg Infect Dis. 2005; 11: 1218-1224https://doi.org/10.3201/1108.050103