Bone remodelling and disorders of bone metabolism

Abstract 

Bone remodelling is critical to bone health. Alterations in the bone remodelling cycle that impact on bone mass and bone strength underlie many of the common disorders of bone metabolism. In this article the effects of altered bone remodelling are reviewed, predominantly in the context of osteoporosis. Consideration is also given to the relationship between altered bone turnover and some of the less common disorders of the skeleton.

Keywords: bone mineral density, bone remodelling, bone turnover, fracture risk, osteoblast, osteoclast, osteoporosis, dual-energy X-ray absorptiometry