Surgery
Volume 26, Issue 5 , Pages 175-182, May 2008

Immunology and principles of transplantation

Philip Dyer PhD FRCPath is a Consultant Clinical Scientist and Professor in Transplantation Science at Manchester Royal Infirmary, UK. He is a Past President of the British Transplantation Society and has published widely in transplantation science. Conflicts of interest: none declared

Abstract 

Treatment of organ failure by transplantation has been established effectively over the past 50 years. The specific individuality of a patient is defined by the immune response, which has evolved for the sole function of maintaining a healthy body by combating infection and malignancy. The clinical need for transplantation has driven our understanding of the immune system and this has allowed effective immune manipulation, giving rise to transplant function and recipient longevity. All transplant recipients must receive long-term immunosuppression as tolerance inducing treatments are not yet practicable.

Keywords: histocompatibility, immune response, immunosuppression, organ allocation, organ donation, organ transplantation

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PII: S0263-9319(08)00034-3

doi:10.1016/j.mpsur.2008.03.006

Surgery
Volume 26, Issue 5 , Pages 175-182, May 2008

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